Interestingly, acetylcarnitine improved mental fatigue while propionylcarntine improved general fatigue.
Carnitine is an amino acid that helps the mitochondria create energy and ATP.
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A study published in the American Journal of Epidemiology of 3,531 British veterans of the Gulf war and the war in Bosnia shows that the incidence of “Multiple Chemical Sensitivity was particularly associated with Gulf deployment and self-reported exposure to pesticides.”
Another study published in the Annals of Occupation Hygiene shows that the incidence of chronic fatigue is correlated to exposure to organophosphate pesticides.Organophosphates are potent neurotoxins and are used in various pesticides, herbicides and nerve gases which works by inhibiting the acetylcholinesterase function in nerve cells.
Two grams of carnitine per day has been shown in a small open-label randomized trial to improve symptoms of Chronic Fatigue Syndrome. Two forms of carnitine were used in this study, acetylcarnitine and propionylcarnitine, where 59% and 63% of subjects reported improvement respectively.
Interestingly, acetylcarnitine improved mental fatigue while propionylcarntine improved general fatigue.
Carnitine is an amino acid that helps the mitochondria create energy and ATP.
66% of patients reported improvements which may include improvements in energy; sleep; mental clarity; pain intensity; and sense of well-being.
D-Ribose is one of the steps in the energy production pathways of the body. A truly significant improvement of fatigue after taking D-Ribose may indicate genetic deficiency in myoadenylate deaminse enzyme.
You can view the study abstract in pubmed. Study ID 17109576.